宫颈腺癌15例临床病理分析

摘要

目的：探讨宫颈腺癌的临床病理特点及鉴别诊断。方法：回顾成都市第一人民医院病理科2012年5月-2014年5月35923例组织学标本中诊断的15例宫颈腺癌，结合免疫组化分析。结果：在35923例组织学标本中，诊断宫颈腺癌15例，占0．04％。15宫颈腺癌中，原发性宫颈腺癌8例，占53％。继发性宫颈腺癌7例，占47％。原发性宫颈腺癌组织学亚型包括：宫颈性腺癌5例，子宫内膜样腺癌2例，绒毛管状腺型1例；继发性宫颈腺癌包括：肠型腺癌2例及子宫内膜样腺癌5例，其免疫组化染色ER（＋）、Vim（＋）、CEA 3例（-），2例灶性（＋）。结论：与宫颈鳞癌相比，宫颈腺癌少见，不易早期发现。临床及免疫组化在宫颈腺癌原发性及继发性的鉴别中有重要意义。%Objective:To investigate the clinicopathologic characteristics ,diagnosis and differential diagnosis of cervical adenocarcinoma .Methods:Clinicopathologic and immunohistochemical data of 15 cases of endocervical adenocarcinoma , diagnosed among 35 923 patients at Chengdu NO .1 people’s hospital pathology department during May 2012 and May 2014 were retrospectively reviewed .Results:The prevalence of cervical adenocarcinoma was 15 of 35 923 (0.04% ) .A-mong 15 cervical adenocarcinomas ,the primary and the secondary tumors were 8(53% ) and 7(47% ) ,respectively .His-topathologically ,the subtype of primary cervical adenocarcinomas were of mucinous endocervical type 5 cases ,of endo-metrioid type 2 cases ,and of villoglandular type 1 case .The secondary cervical adenocarcinomas comprised intestinal type 2 cases and endometrioid type 5 cases ,in which both ER and Vim staining were positive ,and CEA staining was negative in 3 cases and focally positive in 2 cases .Conclusion:Compared with cervical squamous carcinoma ,adenocarci-noma is uncommon ,with difficulties in early detection .Clinic and immunohistochemical data are useful for distinguis-hing primary from secondary cervical adenocarcinoma.