依达拉奉联合普罗布考对急性脑梗死患者血清hs-CRP 、NSE 及神经功能的影响

摘要

Objective :To investigate the therapeutic effect of edaravone and proletarian cloth to test the joint treatment of acute cerebral infarction (ACI) the efficacy and on serum high sensitivity C reactive protein (hs-CRP) ,neuron spe-cific enolase (NSE) and neurological function .Methods :156 patients with ACI were randomly divided into A group and B group ,with 78 cases in each group .The two groups were given conventional treatment ,group A was added with edar-avone and proletarian cloth probucol treatment .Group B added with edaravone and compared between the two groups before and after treatment serum hs CRP ,NSE and neurological function score (NIHSS) changes .Results:The total ef-fective rate in the treatment group was 92 .31% ,significantly higher than that in group B (P<0 .05);the NIHSS score in the two groups were significantly improved after treatment ,and the improvement of A group was significantly high-er than that in B group (P<0 .05);after 14d and 7d in the two groups of serum NSE and hs-CRP were significantly lower ,and the A group was significantly lower than that in B group (P<0 .05) .Conclusion:Edaravone and proletarian cloth test combination therapy in the treatment of acute cerebral infarction (ACI) can significantly reduced hs CRP and NSE levels ,improve the nerve function ,improve the clinical efficacy ,is worthy of popularization and application .%目的：探讨依达拉奉与普罗布考联合治疗急性脑梗死（ACI）的疗效及对患者血清超敏-C反应蛋白（hs-CRP）、神经元特异性烯醇化酶（NSE）及神经功能的影响。方法：将156例ACI患者随机分为A组与B组，每组78例。两组均予以常规治疗，A组加用依达拉奉与普罗布考治疗，B组加用依达拉奉治疗，对比两组治疗前、后血清hs-CRP、NSE及神经功能评分（NIHSS）变化。结果：A组的治疗总有效率为92．31％，显著高于B组的80．77％（P＜0．05）；治疗后两组的NIHSS评分均显著改善，且A组改善幅度显著优于B组（P＜0．05）；治疗后7d及14d两组的血清NSE及hs-CRP均显著降低，且A组显著低于B组（P＜0．05）。结论：依达拉奉与普罗布考联合治疗ACI能够显著降低hs-CRP及NSE水平，改善神经功能，提高临床疗效，值得推广应用。