血清CEA、CA199和CA242对胰腺癌转移诊断的相关性研究

摘要

Objective To explore the the value of serum CEA,CA199 and CA242 in the patients with metastasis pancreatic cancer. Methods Serum CEA,CA199 and CA242 levels were determined with ABBOTT i2000 automatic immune light - emitting device in 72 patients of metastasis pancreatic cancer and in 13 patients of non - metastasis pancreatic cancer. Results High levels of serum markers were assocociated with advanced stage of the pancreatic cancer. The serum CEA,CA199 and CA242 levels in 72 patients of metastasis pancreatic cancer were higher than those in patients of non - metastasis pancreatic cancer( P < 0. 05 ). Conclusion The serum CEA, CA199 and CA242 levels and positive rate in patients of metastasis pancreatic cancer are higher than those in patients of non - metastasis pancreatic cancer. So patients with pancreatic cancer can be detected for serum CEA,CA199 and CA242 concentrations to early judge whether there was transferred.%目的 探讨癌胚抗原(CEA)、糖抗原199(CA199)和糖抗原242( CA242)检测诊断胰腺癌转移的意义.方法 应用美国雅培i2000全自动免疫发光仪检测72例胰腺癌转移患者与13例胰腺癌未转移患者血清中CEA、CA199及CA242浓度.结果 随着胰腺癌患者临床分期的增加胰腺癌患者血清中CEA、CA199、CA242浓度逐渐增加,临床分期Ⅱ期、Ⅲ期、Ⅳ期患者与Ⅰ期患者及正常对照组血清中CEA、CA199与CA242浓度及阳性率比较P＜0.05差异有统计学意义,转移组患者血清中CEA、CA199及CA242浓度与阳性率远高于未转移组P＜0.05,差异有统计学意义.应用ROC曲线比较胰腺癌转移组与未转移组血清CEA、CA199及CA242对胰腺转移癌的联合诊断敏感性达到74.5％特异性达到71.2％,优于CEA、CA199及CA242单项检测.结论 在胰腺癌转移组患者血清CEA、CA199及CA242浓度与阳性率大于未转移组患者；可以检测胰腺癌患者血清CEA、CA199及CA242浓度来早期判断胰腺癌患者有无转移.