ACE2-Ang(1-7)-Mas轴在炎症反应中的作用

摘要

实验和临床研究证实,肾素-血管紧张素系统通过炎症反应参与多种心血管和肾脏疾病的发生发展过程.血管紧张素1-7[Ang(1-7)]是肾素-血管紧张素系统家族的新成员,近年的研究发现其具有重要的生理功能.Ang(1-7)及其合成酶血管紧张素转移酶2(ACE2)和受体Mas组成的ACE2-Ang(1-7)-Mas轴对心血管和肾脏疾病,特别是炎症性心血管和肾脏疾病的影响受到广泛的关注.本文主要就ACE2-Ang(1-7)-Mas轴在炎症反应中的作用及其机制做一简要的综述.%Recent experimental and clinical researches found that renin - angiotensin system (RAS) took part in the onset and process of many cardiovascular and renal diseases by activating inflammation. Angiotensin( 1 -7) , the new family member of RAS, has been found to have important biological functions. The influence of angiotensin( 1 -7) and its synthesize enzyme-angiotensin converting enzyme 2(ACE2) and its receptor-Mas, which is called ACE2 - Ang(1 -7) - Mas axis, on cardiovascular and renal diseases,especially inflammation - related ones, got more and more attention. This review summarized the effect of ACE2 - Ang(1 -7) - Mas axis in inflammation and the macular mechanism involved in.