PHARMACEUTICAL COMPOSITIONS CONTAINING ANGIOTENSIN-CONVERTING ENZYME 2/ANGIOTENSIN-(1-7)/MAS RECEPTOR AXIS ACTIVATORS FOR THE TREATMENT OF OCULAR PATHOLOGICAL CONDITIONS

摘要

The present invention describes pharmaceutical compositions containing angiotensin-converting enzyme 2(ACE2)/angotensin-(1-7)[ANg-(1-7)]/Mas receptor axis and the use thereof for the treatment of ocular pathological conditions linked with an increase in intraocular pressure (IOP) and/or with degeneration of the retina and/or of the optic nerve, such as, for example, glaucoma and retinopathy, preferentially diabetic retinopathy. Such pharmaceutical compositions may be administered by any drug-administration route, preferentially via the oral, topical ocular, intraocular, periocular, conjunctival or intravenous routes, amongst others. The pharmaceutical forms used are, preferentially, solution, suspension, emulsion, capsule (hard or gelatin), tablet, gel, cream, lotion, film, microcapsule, nanocapsule, nanosphere, microsphere, nanoemulsion, microemulsion and/or liposomes.