目的 评价口服盐酸氨基葡萄糖和注射透明质酸钠以及两者联合治疗膝关节骨性关节炎的疗效.方法 采用随机对照临床研究方法,将162例诊断为膝骨性关节炎的患者随机分为3组,口服组、注射组、联合用药组各54例,分别给予口服盐酸氨基葡萄糖480毫克/次,每天口服3次,关节内注射2毫升/次,每周1次.共治疗5周.停药后观察2周.收集3组患者治疗期间Lequesne指数评分和VAS评分,来评估治疗前后膝关节症状变化程度.结果 治疗5周后,口服组、注射组、联合用药组Lequesne总指数比治疗前均有明显下降,分别为3.3±1.6、3.1±1.3、2.8±1.3.联合用药组和其他两组差异具有统计学意义(P＜0.05).VAS评分治疗5周后口服组、注射组、联合用药组分别下降为1.77±0.91、1.66±1.21、1.53±1.13.与治疗前相比均具有统计学差异(P＜0.05).结论 口服盐酸氨基葡萄糖和关节内注射透明质酸钠均对膝骨性关节炎具有良好的疗效,两者联合治疗方式效果优于单独用药治疗方式.%Objective To evaluate the efficacy of glucosamine hydrochloride,hyaluronic acid and combined use of the two drugs in the treatment of patients with knee osteoarthritis. Methods Totally 162 patients suffering from knee osteoarthritis were random divided into 3 groups, and were treated with glucosamine hydrochloride, hyaluronic acid and combined of above two therapies. Patients reveived medicine 3 times daily with total 480mg/d for glucosamine hydrochloride group, intra - articular injection of hyaluronic acid one time a week with 2ml per time and two treatments combined for combined group. Lequesne index and VAS score were recorded at 1,2,3,4,5 weeks during therapy and 1,2 weeks after therapy. Results Lequesne index were obviously decreased at 5 weeks for 3 groups. It was 3.3 ±1.6、3.1 ±1.3、2.8 ±1.3 , respectively. VAS scores were 1.77 ±0.91、1.66 ±1.21、1. 53 ± 1.13 at 5 weeks for 3 groups. Conclusion Glucosamine hydrochloride 、hyaluronic acid were effective in the treatment of knee osteoarthritis. Combined these two therapies was more effective than such treament.
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