恶性肿瘤通过多种机制产生肿瘤耐药.细胞自噬是在生理条件和病理条件下普遍存在的生理机制,不仅能参与维持细胞稳态,还与肿瘤的发生发展和肿瘤耐药密切相关.化疗药物通过抑制磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin,PI3K-Akt-mTOR)信号通路、活化单磷酸腺苷活化蛋白激酶(AMP-activated protein kinase,AMPK)抑制mTOR激酶活性、诱导Beclin 1/Bcl-2复合物解耦联等途径,诱导肿瘤细胞自噬,影响肿瘤细胞对化疗药物敏感性.因此,抑制细胞自噬是对抗肿瘤耐药的潜在途径,抑制肿瘤细胞自噬联合化疗药物的应用,有望成为有效的肿瘤治疗策略.%Malignant tumors resist chemotherapy drugs through a variety of mechanisms . As a general physiological mecha nism under both physiological and pathological conditions , autophagy can not only take part in maintaining homeostasis , but also be closely related with tumor development and resistant . Autophagy can be induced by chemotherapy agents through several ways in cancer cells, such as inhibiting PDK-Akt-mTOR pathway, activating AMPK-mTOR pathway and inducing dissociation of Beclinl/Bcl-2 complex , which exerts an effect on the c he mo sensitivity . Therefore, autophagy is a potential target for antitumor drug resistant . Specific inhibition of autophagy in cancer cells combined with chemotherapy is expected to be an effective cancer treatment strategy .
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