高迁移率族蛋白B1与心血管疾病相关性的研究进展

摘要

High mobility group box 1 protein (HMGB1) is a kind of nucleoprotein. It is secreted by necrosis cells and activated immunocytes into the extracellular environment, which has the activity of a cytokine, and thereby initiates immune responses and cause inflammatory reactions. It has been confirmed by numerous studies that HMGB1 is closely related to heart failure, myocardial ischemia reperfusion injury, atherosclerosis, heart infarction, etc. Studying the mechanism of HMGB1 in the development of angiocardiopathy will find a new target for curing cardiovascular diseases clinically.%高迁移率族蛋白B1(high mobility group box1 protein,HMGB1)是一种核蛋白质,其可由坏死细胞以及活化的免疫细胞释放至细胞外而具有细胞因子的活性,继之启动免疫反应和引发炎性反应.近年来,大量研究证实HMGB1与心力衰竭( heart failure,HF)、心肌缺血-再灌注(ischemia/reperfusion,I/R)损伤、动脉粥样硬化(atherosclerosis,AS)、心肌梗死(myocardial infarction,MI)等疾病有密切关系,通过研究HMGB1在心血管疾病发生发展过程中的机制,可为心血管疾病的临床治疗找到新靶点.