包虫病是一种古老的人畜共患疾病.在世界范围内为均有较高的发病率和致死、致残率.我国西部地区是世界范围内脑包虫病的高发地区,其中青海、西藏、新疆等地因其独特的地理以及人文因素,成为包虫病重灾区.目前针对包虫的药物主要为苯并咪唑类,但是由于该类药物药效不明显及副作用大,我们急切需要研制新药品.文章将基因组学、干细胞、信号通路等方面的包虫新药研制现状做一概述,旨在深入理解目前包虫药物治疗的局限性,总结新药研究的进展,提出可行的研究方向,促使新药研究的发展.%As a local parasitic disease in Qinghai,Tibet,Xinjiang and other places,cerebral hydatid disease has high morbidity and mortality.At present,the main drug for Echinococcosis is benzimidazole.However,due to the lack of efficacy and side effects of these drugs,we urgently need to develop new drugs.In this paper,we gives a brief introduction of the application of genomics,stem cells and signaling pathway knowledge in developing new drugs of hydatid,which aims to understand the limitations of current hydatid medication,summarize the research progress of new drugs,put forward the potential research direction,prompting the development of new drug research.
展开▼
