68例维吾尔族IgA肾病患者MBL基因多态性与临床病理相关性分析

摘要

Objective To investigate the relationship between mannose-binding lectin(MBL)gene polymorphism and clinicopathological features in IgA nephropathy(IgAN)patients with Xinjiang Uygur nationality.Methods 68 patients with biopsy proven IgAN were identified from renal disease database. MBL codon 54 gene polymorphism was detected by PCR-RFLP. MBL genotype and allele frequency were compared between IgAN patients with different clinical manifestations or different patterns of glomerular immune deposits.Results Distribution of MBL codon 54 gene polymorphism showed significant difference between Uygur IgAN patients with proteinuria and simple hematuria. The genotype frequency of GAC heterozygote in Uygur IgAN patients with clinical proteinuria of multiple immune deposits was notably higher in those with clinical simple hematuria(χ~2=5.934,P＜0.05).Conclusion The GAC heterozygote of MBL gene condon 54 wase associated with clinical proteinuria and different patterns of glomerular immune deposits in Uygur IgAN patients.%目的 探讨甘露糖结合凝集素(mannose-binding lectin,MBL)基因第54位密码子多态性与维吾尔族IgA肾病患者临床和病理的关系.方法 应用PCR-RFLP方法对68例维吾尔族IgAN患者进行MBL多态性检测,并与患者临床和病理特点进行相关性分析.结果 ①维吾尔族IgAN中表现为蛋白尿的患者突变型等位基因GAC的发生频率显著高于表现为单纯血尿的患者(P＜0.05);②维吾尔族IgAN中表现为复合性免疫沉积的患者等位基因GAC的发生频率显著高于表现为单纯免疫沉积的患者(P＜0.05).结论 MBL突变型等位基因GAC与维吾尔族IgAN 蛋白尿发生和免疫复合沉积相关.