目的 探讨经阴道彩色多普勒超声联合肿瘤标志物CA125诊断卵巢上皮性肿瘤的临床价值.方法 收集256例患者共273个卵巢上皮性肿瘤病例, 根据术后病理结果分为良性组(175个)、交界性组(25个)及恶性组(73个), 回顾性分析其超声图像特征及肿瘤标记物血清CA125检查结果.结果 发生于左侧卵巢125例, 右侧卵巢114例, 双侧卵巢17例;经阴道超声诊断卵巢肿瘤良、恶性的特异性及敏感性为96.1％;94.6％、经肿瘤标志物CA125诊断的特异性及敏感性为95.4％;83.5％、二者联合诊断的特异性及敏感性为99.4％;94.8％.结论 经阴道彩色多普勒超声联合肿瘤标志物CA125对卵巢上皮性肿瘤诊断及良恶性鉴别优于单一检查方法, 具有重要的临床意义.%Objective To investigate the clinical value of transvaginal color Doppler ultrasound (TVCDU) combined with tumor marker CA125 in the diagnosis of ovarian epithelial tumor. Methods It was a retrospective study. A total of 273 epithelial ovarian tumors from 256 patients were divided into benign group (175 cases), borderline group (25 cases) and malignant group (73 cases) according to postoperative pathological results. Ultrasound image features and tumor marker CA125 test results were retrospectively analyzed. Results 125 occurred in left ovary, 114 in right ovary and 17 occurred in bilateral ovary. The specificity and sensitivity of transvaginal sonography in the diagnosis of benign and malignant ovarian tumors were 96.1％ and 94.6％, respectively. The specificity and sensitivity of tumor marker CA125 were 95.4％ and 83.5％, respectively. The specificity and sensitivity of combined diagnosis were 99.4％ and 94.8％, respectively. Conclusion The combination of transvaginal color Doppler ultrasonography and tumor marker CA125 is superior to single examination in diagnosing benign and malignant ovarian epithelial tumors. It has important clinical significance and can be used as a reasonable and effective method for ovarian cancer.
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