维生素D缺乏在小儿毛细支气管炎发病中的作用

摘要

Objective:To investigate the effects of vitamin D deficiency in the pathogenesis of bronchioli-tis in children.Methods:50 cases of children with VitD deficiency were selected,who were randomly divided into the experimental group and the control group,all children underwent anti-infection and symptomatic treatment.The experimental group was given additional VitD for 1 months.The levels of serum 25-(OH)D3 and IgA before treatment were detected in two groups,and the levels of 25-(OH)D3 and IgA were detected again after 1 month.The disappearing time of paroxysmal wheeze,pulmonary signs and admission duration were recorded.Results:The disappearing time of paroxysmal wheeze,pulmonary signs and admission dura-tion in the experimental group were significantly shorter than the control group (t=2.03,2.49,3.23,all P<0.05).There was no significant difference in the levels of serum 25-(OH)D3 and IgA of children before treatment between the two groups (P>0.05).After treatment,the levels of 25-(OH)D3 and IgA in the ex-perimental group were significantly higher than those in the control group (t=8.28,9.57,all P<0.01);af-ter treatment,the levels of 25-(OH)D3 and IgA in the experimental group were significantly increased than that before treatment (t=8.28,9.57,all P<0.01).Conclusion:Children with bronchiolitis have lower levels of serum 25-(OH)D3and IgA,supplementary VitD helps to relieve clinical symptoms,which indicates VitD may regulate the immune function to effect treatment of bronchiolitis,and has popularization value in clinical application.%目的：：观察维生素D(VitD)缺乏在小儿毛细支气管炎发病中的作用。方法：选择 VitD 缺乏的毛细支气管炎患儿50例,随机数字表法分为实验组与对照组,所有患儿均给予抗感染及对症治疗,同时实验组给予补充 VitD治疗,疗程1个月。检测两组患儿治疗前血清25-(OH)D3及IgA水平,1个月后复查25-(OH)D3及IgA水平。记录两组各项指标(患儿喘憋消失时间、肺部体征消失时间、住院天数)。结果：实验组患儿喘憋消失时间、肺部体征消失时间、住院天数较非对照组明显缩短(t=2.03、2.49、3.23,P 均<0.05)。治疗前两组血清25-(OH)D3及IgA差异无统计学意(P>0.05)。治疗后实验组25-(OH)D3及 IgA水平明显高于对照组(t=8.28、9.57,P 均<0.01)；治疗后实验组25-(OH)D3及IgA水平较治疗前有显著提高(t=8.28、9.57,P 均<0.01)。结论：毛细支气管炎患儿血清25-羟维生素D3及IgA水平低下,补充 VitD有助于缓解临床症状,提示 VitD可能通过调节机体免疫功能进而影响毛细支气管炎的治疗,其在临床中的应用具有推广应用价值。