Role of PAI-1 in adipose tissue senescence and inflammation in obesity

摘要

Plasminogen activator inhibitor-1(PAI-1)is a member of the evolutionarily conserved serine pro⁃tease inhibitor family.The increased expression of PAI-1 leads to pathological diseases such as vascular diseases,obesity,and metabolic syndrome.Senescence-associated secretory phenotype(SASP)mediates tissue damage and plays a role in adipose tissue dysfunction.Chronic inflammation in adipose tissue is associated with the development of metabolic diseases,including obesity,insulin resistance,and type 2 diabetes.PAI-1 plays a vital role in adipose tissue physiology,glucose metabolism,insulin secretion and sensitivity,inflammation,and macrophage chemotaxis.This article reviews the possible role of PAI-1,as one of the SASP markers,and speculates the potential role of PAI-1 in adipose tissue senescence and inflammatory macrophage infiltration in obesity.