目的:研究腹腔镜结直肠癌根治术后经脐静脉化疗泵持续灌注5-FU对减少术后肝转移、提高远期疗效的作用.方法:为106例患者行腹腔镜结直肠癌根治术,随机分为脐静脉化疗组(研究组,n =53)和对照组(n=53).研究组术中经脐静脉向门静脉插管,术后即从脐静脉化疗泵持续给予5-FU 1g/d,连续7d.对比分析两组近期并发症和远期疗效.结果:两组术后住院时间及术后近期并发症差异无统计学意义(P>0.05),研究组术后3年肝转移率明显低于对照组(12.3% vs.32.9%,P=0.023),而3年生存率显著高于对照组(83.6% vs.63.9%,P=0.033).结论:腹腔镜结直肠癌根治术后即经脐静脉化疗泵持续灌注5-FU能明显降低肝转移,提高生存率.%Objective :To investigate the effect of 5-Fluorouracil (5-FU) infusion through umbilical vein pump for 7 days on preventing liver metastasis and improving the survival rate after laparoscopic radical resection for colorectal cancer. Methods:The 106 colorectal cancer patients with laparoscopic radical resection were divided into portal vein chemotherapy group (study group,n ＝ 53 ) and control group (n ＝53) randomly. In study group,5-FU were infused 1.0g per day constantly for 7 days after operation through umbilical vein pump, the 5-FU was placed into portal vein through umbilical vein. The short-term complications and long-tem effect were compared between the two groups. Results:There were no significant differences in hospital stay and short-term complications between the two groups( P ＞0.05 ). The 3-year liver metastasis rate in study group was significantly lower than that in control group( 12.3％ vs. 32.9％, P ＝ 0. 023 ), and the 3-year survival rate in study group was significantly higher than that in control group(83.6％ vs. 63.9％, P ＝ 0. 033 ). Conclusions :5-FU consistent infusion through umbilical vein pump after laparoscopic radical resection for colorectal cancer can lower liver metastasis and improve survival rate.
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