经典Wnt信号通路在骨肉瘤中作用的研究进展

摘要

骨肉瘤是骨组织中最常见的恶性肿瘤,恶性程度高,易发生于儿童和青少年.Wnt信号通路是一条含有高度保守的碱基序列的信号通路,它调控细胞极性、增殖、分化,胚胎发育,组织稳态及细胞癌变,肿瘤细胞侵袭转移等众多生物过程.经典Wnt信号通路与骨肉瘤的发生、发展关系密切,在骨肉瘤细胞增殖、侵袭转移等方面的重要调控作用为骨肉瘤发病、转移机制以及化疗耐药方面的研究提供了重要方向和方法.%Osteosarcoma is the most common malignant tumor in bone tissue, whose high degree of malignancy especially preys on children and adolescents. Wnt signaling pathway is a signal pathway containing a highly conserved base sequence that regulates cell polarity, proliferation, differentiation and embryo development, tissue homeostasis and cell carcinogenesis, tumor cell invasion and metastasis and many other biological processes. The study found that classical Wnt/β signaling pathway and the occurrence and development of osteosarcoma were closely related. classical Wnt/β signaling pathway in osteosarcoma cell proliferation, invasion and metastasis and other important regulations could provide an important direction and method research into the pathogenesis of osteosarcoma and metastasis mechanism and chemotherapy resistance.