Objective To observe the expression levels of 8 - hydroxy-deoxyguanosine (8-OHdG) in patients with different glucose metabolism and its relationship with islet dysfunction.Methods Based on the 75 g oral glucose tolerance test (OGTT), the patients were divided into 3 groups: normal glucose tolerance (NGT) group (30 patients), isolated impaired glucose tolerance (IGT) group (28 patients), type 2 diabetes mellitus (T2DM) group (28 patients), and 30 healthy subjects were selected as the healthy control group (healthy control, HC) . The triglyceride (TG) and total cholesterol (TC), glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), insulin resistance index, insulin and c-peptide area under the curve (AUC) were detected, and compared between groups, and the correlation between 8-OHdG and these indexes was analyzed. Results There was no difference in FBG values between NGT group and HC group, the indicators of patients in other groups were higher than HC group,the difference was statistically significant (P<0.01). The values of FBG, 8-OHdG, HbA1C and HOMA-IR of patients in IGT group were higher than NGT group, the difference was statistically significant (P<0.01) . The values of FBG ,8-OHdG, HbA1C and HOMA-IR in T2DM group were higher than IGT group. There were no differences in insulin AUC between NGT group, IGT group and T2DM group (P> 0.05) . 8-OHdG was correlated with FBG, HbA1c, HOMA-IR, C peptide AUC, insulin AUC, and the correlation coefficients were 0.704, 0.713, 0.665, 0.825 and 0.653, respectively, the differences were statistically significant. Conclusions 8-OHdG levels can reflect the status of islet dysfunction,and can be used as an indicator of islet function for diabetic patients.%目的观察8-羟基脱氧鸟苷（8-OHdG）水平在不同糖代谢患者中的表达水平，探讨其与胰岛功能损害的相关关系．方法依据75 g葡萄糖耐量试验（OGTT）分为正常糖耐量（NGT）组30例，单纯糖耐量异常（IGT）组28例，2型糖尿病（T2DM）组28例，并设立健康对照组（healthy control，HC）30例，检测患者三酰甘油（TG）和总胆固醇（TC），糖化血红蛋白（HbA1c），空腹血糖（FBG），计算胰岛素抵抗指数，胰岛素及c肽曲线下面积（AUC），比较各组间差异，并分析8-OHdG与各指标的相关关系．结果除NGT组FBG值与HC组间无差异外，其它组各指标均高于HC组，差异有统计学意义（P＜0.01）；IGT组FBG、8-OHdG、HbA1C、HOMA-IR高于NGT组，差异有统计学意义（P＜0.01）；T2DM组FBG、8-OHdG、HbA1C、HOMA-IR高于IGT组．胰岛素AUC在NGT、IGT和T2DM组间无差异（P＞0.05）；8-OHdG与FBG、HbA1c、HOMA-IR、C肽AUC、胰岛素AUC均有相关性，相关系数依为0.704，0.713，0.665，0.825，0.653，差异均有统计学意义．结论8-OHdG水平能够反应胰岛功能受损的状态，可作为判断糖尿病患者胰岛功能的检测指标．
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