CD4＋T 淋巴细胞与桥本氏甲状腺炎

摘要

桥本氏甲状腺炎（hashimoto’s thyroiditis ，HT ）是引起甲状腺功能减退最常见的甲状腺疾病，在HT 患者中有10％～15％可发生亚临床甲减，有0．1％～2％可发生临床甲减[1]。至今为止，HT 的发病机制尚未完全阐明，其作为一种自身免疫性甲状腺疾病，CD4＋ T 淋巴细胞及其细胞因子在该病的发生发展中扮演着重要的角色，本文就其与 HT 关系的研究进展作一综述。%Hashimoto’s thyroiditis (HT) is the most common cause of hypothyroidism in thyroid disease .It is reported that there are 10% ~ 15% of HT will result in subclinical hypothyroidism ,and 0 .1% ~ 2% will result in hypothyroidism .So far ,the pathogenesis of HT is not fully understood .As an autoimmune thyroid disease ,CD4 + T lymphocytes and their cytokines play an important role in the development of the disease .This review provides a summary of the relationship between CD4 + T lymphocytes and their cytokines with Hashimoto’s thyroiditis .