膀胱癌浸润转移与纤维蛋白含量表达相关性研究

摘要

Objective:To explore the mechanism of infiltration and transfer of bladder carcinoma. Meth-ods:Ager single diffusion method and immunoenzyme technique were adopted to determine the level anddistribution of fibrin in serum and tissues of bladder carcinoma. Results :Fibrin level in patients with blad-der carcinoma significantly decreased than that in control (P＜0. 01). In tissues of bladder carcinoma,mostpart of FN was expressed in cellular matrix,and a little FN was on the surface of cell membrane. Positiveexpression in transfer bladder carcinoma significantly decreased than that in non-transfer bladder carcino-ma. Conclusion :FN level relates to the infiltration and transfer in bladder carcinoma patients.%目的：探讨膀胱癌浸润、转移机理。方法：应用琼脂糖单向扩散法和免疫酶染色技术(ABC法)检测膀胱癌病人血清及膀胱癌组织中纤维结合蛋白(FN)的含量及分布。结果：膀胱癌病人血清中FN含量明显低于正常对照组，统计学处理差异非常显著(P<0．01)，膀胱癌组织中FN表达于细胞基质中，少部分表达于细胞膜表面，且转移癌与非转移癌阳性表达差异显著。结论：FN含量与膀胱癌浸润、转移有关。