妊高征血浆环核苷酸含量的变化

摘要

Objective:To evaluate the effect of the plasma cyclic nucleotide in patients with pregnancy-in-duced hypertension. Methods :To observe the level of the plasma cAMP by radio competitive protein bind-ing assay and level of the p lasma cGMP by radioimmunoassay (RIA). Results:The contents of the plasmacAMP and cGMP were significantly higher in PIH group than those in the controls. Plasma cAMP showedthe negative correlation to postpartum MAP. Conclusion:cAMP and cGMP had synergy on antagonizingthe contraction evoked by Ca2+. This was an effective compensatory protective mechanism of PIH.%目的：探讨血浆环核苷酸在妊高征中的变化以及作用。方法：采用竞争性蛋白结合分析的方法及其放射免疫方法测定25例重度妊高征和27例正常妊娠晚期妇女(对照组)血浆中环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)的含量。结果：妊高征患者血浆cAMP和cGMP的浓度远远高于正常对照组，并且妊高征产后组明显低于产前组。产前cAMP与产后平均动脉压(MAP)之间呈明显的负相关。结论：cAMP和cGMP在妊高征中表现出相互协同的作用，共同拮抗细胞内Ca2+升高引发的血管收缩。