红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

摘要

Objective: To evaluate the clinical therapeutic efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne vulgaris.Methods:Eighty patients with moderate to severe acne vulgaris were randomly divided into Xihuang Capsules group (control group)and red-blue light irradiation combined with Xihuang Capsules group (observation group).The patients in observation group were treated with red-blue light irradiation (20 min biw,4 weeks)combined with Xihuang Capsules (1.5 g bid,4 weeks),while the patients in control group took only Xihuang Capsules orally (1.5 g bid,4 weeks),The changes of skin lesions and adverse reactions were observed and the curative efficacies were compared at 2 or 4 weeks after treatment.Results:After 2-week-treatment,the total effective rate in observation group was 67.5% while the total effective rate in control group was 52.5%,there was no statistically significant difference between two groups (P >0.05).The regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P <0.05).After 4-week-treatment,the total effective rate in observation group was significantly higher than that in control group (85.0% vs 65.0% ),and the difference was statistically significant (P < 0.05);the regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P <0.05).During the treatment,there were no severe adverse reactions in two groups.Mild headache and nausea occurred in observation group after red-blue light irradiation,but the above symptoms disappeared after reducing the irradiation dose.Conclusion:Red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne is proved to be a significantly effective and safe method,and it is worth to be promoted in clinic.%目的：采用红蓝光照射联合西黄胶囊治疗面部中重度痤疮，并评价其疗效及安全性。方法：80例中重度痤疮患者随机分为西黄胶囊组（对照组）和红蓝光照射联合西黄胶囊组（观察组），每组40例。对照组患者口服西黄胶囊，每次1.5 g，每日2次；观察组患者采用红蓝光照射治疗，每次20 min，每周2次，同时口服西黄胶囊，每次1.5 g，每日2次；治疗时间均为4周。治疗后2和4周各随访1次，观察患者皮损变化情况及不良反应发生情况，比较其疗效。结果：治疗2周后，观察组总有效率为67.5％，对照组为52.5％，2组总有效率比较差异无统计学意义（P ＞0.05），但观察组患者炎性皮损和非炎性皮损消退数目明显多于对照组（P ＝0.002和 P ＝0.005）；治疗4周后，观察组总有效率为85.0％，对照组总有效率为65.0％，观察组疗效明显优于对照组（P ＜0.05），且观察组患者炎性皮损和非炎性皮损消退数目均明显多于对照组（P ＝0.01和 P ＝0.001）。治疗期间2组患者均未见严重不良反应，观察组仅有2例患者在红光照射治疗后有轻度头痛及恶心症状，下调照射剂量后症状消失。结论：红蓝光照射联合西黄胶囊治疗面部中重度痤疮具有见效快、疗效好、安全性高的优势，值得在临床上推广应用。