调控神经干细胞迁移的分子网络机制与潜在药物靶点

摘要

神经干细胞(NSC)治疗是目前改善脑卒中和神经退行性疾病等症状的主要手段.本文结合国内外研究进展,系统分析了趋化因子、脑源性神经营养因子、血管内皮生长因子等促NSC迁移的关键分子靶标,阐明PI3K/Akt、MAPK/ERK、JAK/STAT等通路间相互关系和重要节点,有助于理解促NSC迁移药物的分子网络机制,为研发促NSC迁移的创新药物提供靶点和思路.%At the moment,neural stem cells(NSC)therapy is one of the main means to improve stroke and neurodengenera?tive disease. This paper analyses the key molecular targets that promote NSC migration,such as chemokines,brain-derived neuro?trophic factor and vascular endothelial growth factor,and clarifies the relationships as well as important nodes between pathways,like PI3K/Akt,MAPK/ERK,and JAK/STAT.It is helpful to understand the molecular network mechanisms of NSC migration and provide ideas and targets to design creative drugs to promote NSC migration.