妊娠滋养细胞疾病(GTD)是一组具有不同临床、形态学和生物学特性的异质性疾病,其共同特征为滋养层异常.葡萄胎虽属于妊娠滋养细胞疾病中的良性病变,但有潜在恶变的危险.目前主要依据密切监测血清人绒毛膜促性腺激素(hCG)衰减曲线来检查潜在的恶性病变.最近几年,随着实验室诊断技术的改进和各项检测设备的发展,有关能早期发现葡萄胎恶变的遗传学、各项生化指标及影像学改变的报道越来越多,试图获得精确而早期的疾病诊断.简述这些有意义的葡萄胎恶变预后指标.%Gestational trophoblastic disease(GTD)is a group of heterogeneity diseases with different clinical,morphological and biological characteristics. Its common feature lies in trophoblastic abnormality. Although hydatidiform mole is a benign disease of the gestational trophoblastic diseases, it has the potential risk of malignant transformation. At present we are mainly based on closely monitoring the serum human chorionic gonadotropin (hCG)attenuation curve to check the underlying malignant lesion. In recent years, with the development of laboratory diagnostic techniques and detection equipments, there are more and more alterations in genetics, biochemical indicators and sonography reported to predict the malignant transformation of hydatidiform mole,trying to obtain precise and early diagnosis of this situation. This article is aimed to briefly introduce these significant prognostic indicators.
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