宫颈大细胞神经内分泌癌

摘要

宫颈大细胞神经内分泌癌(LCNEC)是一种罕见类型的宫颈恶性肿瘤,因其恶性程度高、进展迅速、复发率高,易早期发生血行转移,故预后极差.高危型人乳头瘤病毒(HPV)感染是其主要病因.虽然细胞学异常有助于其早期诊断,但组织病理形态学联合免疫组织化学检查才是对其进行诊断及鉴别诊断的主要方法.目前宫颈LCNEC尚无统一的治疗方案,但多数学者认为手术辅以放疗和化疗的综合治疗有助于提高患者生存率.%Large cell neuroendocrine carcinoma (LCNEC) of the cervix is a rare cervical malignancy. The prognosis of LCNEC of the cervix is very poor showing a high degree of malignity,a rapid progression,a high relapse rate and early blood spread. Its development is closely related to high-risk human papilloma virus infection. Although the cytologic abnormality can aid to the diagnosis of LCNEC of the cervix,the pathologic examination combined with immunohistochemical study is the main method for its diagnosis and differential diagnosis. There is no unified therapy at present,but a majority of scholars presume that operation combined with radiotherapy and chemotherapy can improve the survival rate.