The present disclosure provides methods of treating mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis, and/or mast cell gastroenteritis. In particular, the present disclosure relates to mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis and/or mast cell via administration of an antibody that binds to human Siglec-8 or a composition comprising said antibody. A method of treating gastroenteritis is provided. The present disclosure also provides an article of manufacture comprising an antibody that binds to human Siglec-8 for the treatment of mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis and/or mast cell gastroenteritis. or kits.
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