卵巢早衰诊治进展

摘要

Premature ovarian failure (POF) is a common gynecologic endocrine disease. The cause of POF is complex and diverse. Genetic,autoimmune disease,infection,iatrogenic factors all can induce POF,but the etiology of more than 50%POF patients is still unclear. The clinical manifestations of POF are complex and varied ,early diagnosis is difficult and it takes an average of five years to be confirmed. Vaginal ultrasound,hormone level determination,anti-Müllerian hormone and inhibin B can predict ovarian function in a certain degree. Because of significant impact on physical and psychological health ,early diagnosis and treatment are significantly important. For POF patients ,hormone replacement is the main therapy to relieve menopausal symptoms,but donating oocyte for IVF is the important method to solve fertility problems. Self-ovarian transplantation,ovarian and follicle vitrification technologies bring more hope for the infertility patients.%卵巢早衰（premature ovarian failure，POF）是妇科内分泌领域常见的疾病，病因复杂多样，遗传、自身免疫性疾病、感染、医源性因素等均可引起POF，但超过50%的POF患者病因不清。 POF临床表现复杂多样，早期诊断困难，确诊平均需要5年。阴道超声、激素水平、抗苗勒管激素及抑制素B等在一定程度能预测卵巢功能。 POF对患者身心健康产生重要影响，因此其早期诊断与治疗至关重要。目前主要治疗方法是激素替代疗法缓解绝经症状、赠卵辅助生殖技术解决生育问题。自身卵巢移植术、卵巢及卵泡冷冻技术等新方法给患者带来希望。