洛美沙星的示波极谱法测定及其电化学行为

摘要

在 Britton - Robinson－ 0.02 mol/L KCl(pH 8.77) 底液中 , 洛美沙星在汞电极上有一灵敏的导数还原峰 , 峰电位 Vp=－ 1.465 V(vs SCE), 导数峰高与洛美沙星的浓度在 5.0× 10－ 7～ 1.0× 10－ 5 mol/L范围内呈线性关 (r=0.999 6) 检出限为 2.0× 10－ 7 mol/L。该法可应用于片剂和尿样中洛美沙星的含量测定。该文还对洛美沙星在汞电极上的电化学行为进行了探讨。%In a supporting electrolyte of Britton -Robinson-0.02 mol/L KCl（ pH 8.77） , a sensitive derivative reduction peak of lomefloxacin in potential of -1.465 V(vs SCE) was found by single -sweep oscillopolarography. The relationship between the peak height and the concentration of lomefloxacin is linear from 5.0× 10-7 to 1.0× 10-5 mol/L. The detection limit is 2.0× 10-7 mol/L. The method was applied to the determination of lomefloxacin in the sample of tablets and urine with satisfactory results. The electrochemical behavior of lomefloxacin at Hg electrode was also explored.