基于质谱分析的代谢组学研究进展

摘要

质谱分析技术是代谢组学研究的重要技术之一.该文通过近5年来的文献分析,对基于质谱分析的代谢组学研究方法的新进展,包括样品前处理方法、分析检测方法、数据处理方法等,以及近年来代谢组学在疾病诊断、药物研发、营养学、毒理学、运动医学等领域的应用进展,进行了较全面的综述,并对未来的发展趋势进行了展望.%Mass spectrometry (MS) is one of the most important analytical technologies for metabolomics.In recent years,metabolomics based on MS has been widely used in disease diagnosis,drug effect research,nutrition,toxicology,sports medicine,etc.This paper reviews the sample pretreatment,analytical tools,data processing method and main application fields in the past five years.The development tendency of metabolomics in future is also proposed.