Objective:On patients with chronic hepatitis b serum "two half-and-half" inspection result model and hepatitis related antibodies ( ANA, AMA, LKM, LC-1, SLA and ANA spectrum correlation,to clarify the HBV infection caused by autoimmune hepatitis pathogenesis and develop new treatment strategies to provide experimental basis. Methods:From 2012-12-01~2012-12-01 in our hospital treatment of 500 cases patients with chronic hepatitis b ( CHB ) as the research object, by adopting the method of retrospective study. According to the serum "two half-and-half" inspection result,the research object is divided into five model group,namely A,B,C,D,E five group;Each team will then autoantibodies associated with hepatitis(ANA,AMA,LKM,LC-1,SLA and ANA spectrum comparison, the final statistical analysis. Results:( 1 ) between groups associated with hepatitis autoantibody positive comparison:D, E ANA in the two groups, the AMA, LKM, LC-1, the SLA between difference(P>0. 05). A,B,C three groups in the ANA,AMA,LC-1 and in the same group the difference between the other hepatitis related autoantibodies(P<0. 05);Group A and B,C,D,E ANA in four groups,the AMA,LKM,the difference between LC-1(P<0. 05);Group B and C,D,E ANA,AMA in four groups,the difference between LC-1(P<0. 05);Group C and D,E ANA,AMA in four groups,the difference between LC-1(P<0. 05). (2)each group was compared with the enzyme spectrum ANA:A, D, E in the three groups of U 1-n RNP antibody resistance, resistance to Sm antibodies,resistance to M 2 difference(P>0. 05)between each other. B and C in the two groups of re-sistance to M 2 antibodies with this group of the rest of the two kinds of differences(P<0. 05);And,B and C in the two groups of resistance to M 2 antibodies and resistance to M 2 antibodies in A, D, E group differences(P<0. 05). Conclusion:Hepatitis related autoantibodies is mainly related to the big 3 this world,small 3 this world,small 2 Yang;ANA,AMA,LKM,LC-1,the positive detection rate of SLA may have close relationship with the activity of the hepatitis b virus;ANA enzyme spectrum associated with chronic hepatitis b antibodies mainly for resistance to M 2,mainly exist in the patients with small 3 this world and small 2 Yang.%目的：：探讨慢性乙肝病人血清“两对半”检验结果模式与肝炎相关自身抗体( ANA、AMA、LKM、LC-1、SLA及ANA谱)之间的相关性,为阐明HBV感染所致的自身免疫性肝炎发病机制和制订新的治疗策略提供实验依据。方法：选取2012-12-01~2014-12-01在我院治疗的500例慢性乙型肝炎( CHB)病人为研究对象,采用回顾性方法进行研究。根据血清“两对半”检验结果,将研究对象分为5个模式组,即A、B、C组、D、E五组；然后将各组与肝炎相关自身抗体( ANA、AMA、LKM、LC-1、SLA及ANA谱)进行比较,最后统计分析。结果：(1)各组与肝炎相关自身抗体阳性的比较：D、E两组中ANA、AMA、LKM、LC-1、SLA相互之间的差异(P>0.05)。 A、B、C三组中ANA、AMA、LC-1与同组中其它肝炎相关自身抗体之间的差异(P<0.05)；A组与B、C、D、E四组中的ANA、AMA、LKM、LC-1之间的差异(P<0.05)；B组与C、D、E四组中的ANA、AMA、LC-1之间的差异(P<0.05)；C组与D、E四组中的ANA、AMA、LC-1之间的差异(P<0.05)。(2)各组与ANA酶谱的比较：A、D、E三组中抗U 1-n RNP抗体、抗Sm抗体、抗M 2抗体相互之间的差异(P>0.05)。 B、C两组中抗M 2抗体与本组其余两种抗体之间的差异(P<0.05)；并且,B、C两组中抗M 2抗体与A、D、E组中抗M 2抗体之间的差异(P<0.05)。结论：肝炎相关自身抗体主要与大三阳、小三阳、小二阳相关；ANA、AMA、LKM、LC-1、SLA的阳性检出率可能与乙肝病毒的活动性有密切的关系；ANA酶谱中与慢性乙型肝炎相关的抗体主要为抗M 2抗体,主要存在于小三阳和小二阳病人。
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