Objective To study the relationship between the hepatitis B virus (HBV) two in patients with chronic hep-atitis B (CHB) and the correlation between the results of the test results and the correlation between the autoantibodies. Methods 250 cases of CHB patients in January 2014 to January 2016 in our hospital were collected and classified ac-cording to serum HBV markers detection results for group A (big 3 this world, 47 cases), group B (small 3 this world, 53 cases), group C (P2 Yang, 53 cases), group D (single male, 49 cases) and group E (48 cases), analysis compared the autoimmune antibodies. Results The positive rate of ANA antibody in A group, B group and C group was significantly higher than that in D group and E group (P<0.05), D showed no significant difference between group E and group (P>0.05), and A group was significantly higher than that of B group and C group, B group was significantly higher than that of C group (P<0.05); A group patients with positive ANA ds-DNA antibody positive rate was 45.24%, ANA negative with ds-DNA antibody positive in 0 cases, there was significant difference between two groups (P< 0.05); B group of patients with positive ANA ds-DNA antibody positive rate was 30.77%, ANA negative and ds-DNA positive rate of 7.41%, there was significant difference between two groups (P< 0.05); C group of patients with positive ANA ds-DNA antibody positive rate was 18.75%, significantly higher than the ANA negative with ds-DNA antibody positive patients (P < 0.05); D group and E group were ds-DNA antibody positive patients. Conclusion In CHB patients with HBV markers detection result size Sanyang and P2 Yang and hepatitis related autoantibodies are closely related, in the dis-cussion of hepatitis B, development and the etiology of study has very important value.%目的：研究慢性乙型肝炎(CHB)患者的血清乙肝两对半检验结果模式与肝炎相关性自身抗体之间的关系。方法收集2014年1月—2016年1月该院收治的CHB患者250例,根据血清乙肝两对半检测结果分为A组(大三阳,47例)、B组(小三阳,53例)、C组(小二阳,53例)、D组(单阳,49例)和E组(其他,48例),分析比较各组的自身免疫性抗体情况。结果 A组、B组、C组的ANA抗体阳性率显著高于D组及E组(P<0.05),D组与E组间比较差异无统计学意义(P>0.05),且A组显著高于B组及C组,B组显著高于C组(P<0.05)；A组ANA阳性伴ds-DNA抗体阳性率45.24%,ANA阴性伴ds-DNA抗体阳性0例,两组比较差异有统计学意义(P﹤0.05)；B组ANA阳性伴ds-DNA抗体阳性率30.77%,ANA阴性伴ds-DNA抗体阳性率7.41%,两组比较差异有统计学意义(P﹤0.05)；C组ANA阳性伴ds-DNA抗体阳性率18.75%,显著高于ANA阴性伴ds-DNA抗体阳患者(P﹤0.05)；D组与E组均无ds-DNA抗体阳性患者。结论 CHB患者的乙肝两对半检测结果中大小三阳及小二阳与肝炎相关性自身抗体密切相关,其在探讨乙型肝炎发生、发展与病因的研究中具有十分重要的价值。
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