Objective:To observe the effects of three-dimensional conformal radiotherapy ( 3 D-CRT) later-course combined with Endostar in the treatment of elderly patients with advanced non small cell lung cancer(NSCLC)the recent therapeutic effect and side reaction. Methods:60cases of elderly patients with locally advanced NSCLC patients in our hospital,were randomly divided into two groups, the later-group ( 30cases ):treated with Endostar combined with 3D-CRT late course, from the conformal radiotherapy PTV dose to 40 Gy began, until the end of radiotherapy, radiation every time before 30 min 15 mg intravenous infusion of Endostar;3D-CRT group(30cases):the use of 3D-CRT alone. Efficacy evaluation was performed with RECIST’s WHO standard,and the efficacy and toxicity of 3months after the end of treatment were compared with that of 12months. Results:Late course group and 3D-CRT group after 3months of clinical benefit rate(Cr +PR +SD)were 96. 7%and 86. 7%,P=0 . 350 . The total response rate ( Cr + PR ) were 73 . 3%and 60 . 0%, P=0 . 412;Two groups of 1 year clinical benefit rate was 86 . 7% and 73 . 3%, P=0 . 333;similar common adverse reaction of two groups,P>0. 05,differences had no statistical significance between the two groups;two groups of 1 year total efficiency,course group was 83. 3%better than simple radiotherapy group 56. 7%,P=0. 047,the difference is statistically significant. Conclusion:Endostar combined with 3D-CRT treatment of locally advanced non small cell lung cancer with 3D-CRT treatment to improve the total efficiency of 1 year, the toxic and side effects of the two groups are similar,Later-course group did not increase treatment-related adverse events.%目的：：观察三维适形放疗(3D-CRT)后程联合恩度治疗老年晚期非小细胞肺癌( NSCLC)的近期疗效和治疗副反应。方法：将我科收治的60例老年局部晚期NSCLC病人随机分为两组,后程组(30例)：采用3D-CRT后程联合恩度治疗,从适形放疗PTV剂量达到40Gy开始,直至放疗结束,每次放疗前30min给予恩度15mg静脉滴注；单纯组(30例)：采用单独3D-CRT.以WHO的RECIST标准进行疗效评价,分别比较治疗结束后3mo的治疗有效率和毒副反应及1a时的治疗有效率。结果：后程组和单纯组治疗后3mo的临床受益率( CR+PR+SD)分别为96.7%和86.7%,P=0.350；总有效率( CR+PR)分别为73.3%和60.0%,P=0.412；两组的1a临床受益率分别为86.7%和73.3%,P=0.333；两组常见的毒副反应相近,P>0.05,两组间比较差异均无统计学意义；两组1a的总有效率,后程组为83.3%优于单纯放疗组的56.7%,P=0.047,差异有统计学意义。结论：恩度联合3D-CRT治疗局部晚期非小细胞肺癌与单纯3D-CRT治疗比较,提高了1a总有效率,两组毒副反应相近,后程组未增加治疗相关副反应。
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