亚太地区抑癌基因p16及runx3甲基化与肝癌易感性关系的Meta分析

摘要

Objective:To evaluate the relationship of p16 and runx 3 methylation with Hepatic car-cinomain in Asia-Pacific region by meta-analysis. Methods:Articles related to the p16 methylation and Hepatic carcinomain published from 1978 to 2014 in the databanks including MEDLINE,Pubmed and published from 1994 to 2013 in the databanks including CNKI,Chinese biological medicine disk, WanFang and VIP databanks were collected, and data was analyzed by RevMan software. Results:Twenty-one studies met our inclusion criteria,eight articles on runx 3 gene and thirty articles on p16 gene were included. Combined data showed,the odds ratio(OR)of P16,runx 3 methylation in case group and control group were 17. 24 and 6. 33, respectively,95%CI were 7. 54 ~39. 40 and 3. 79 ~10. 58,respectively. There both were statistical significance(P<0. 05). Conclusion:There was close relationship between P16 and runx 3 gene methylation with Hepatic carcinomain.%目的：：应用 Meta 分析的方法评价亚太地区抑癌基因p16及runx3甲基化与肝癌易感性的关系。方法：检索1978~2014年在Medline、Pubmed 数据库以及1994~2014年 CNKI、中国生物医学文献数据库、万方和维普数据库收录的所有有关 p16及runx3甲基化与肝癌研究的文献,并用 Review Manager软件进行统计分析。结果：纳入国内外标准的文献共21篇,研究runx3基因的有8篇,研究p16基因的有13篇。数据合并结果显示, p16、runx3病例组与对照组甲基化的比值比(OR)分别为17.24和6.33,95%CI分别为(7.54~39.40)和(3.79~10.58)；经统计学分析差异都具统计学意义(P<0.05)。结论：p16及runx3甲基化与肝癌发生有密切关系。