Aiming at enhancing the reliability of breast diffuse optical tomography, a combined time-domain diffuse fluorescence and optical tomography system is proposed based on the multi-channel time-correlated single-photon counting technique. Aligning 32 coaxial fibers around the tissue surface equally; the system scans objects in a parallel-beam mode analogous to X-ray CT so that the time-resolved projections at different incident positions can be obtained. By applying the relevant iteration reconstruction algorithm, promising images have been produced from measurements on different phantoms. The results indicate this system works reliably and is one of the ideal platforms for optical breast tumor diagnosis.%为了解决传统乳腺扩散光学层析成像可靠性低的问题,设计了一套基于多通道时间相关单光子计数的时域扩散荧光—光学层析成像系统.该系统采用32根同轴光纤均匀分布于组织体表面,作类似X射线层析工作方式的同层扫描,由此获得多角度下的时间分辨投影.通过测量不同仿体,应用相应的迭代图像重建算法,获得了可靠的重建结果.研究表明,该系统工作可靠,是进行乳腺肿瘤早期诊断研究的理想模式之一.
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