中医药辅助治疗卒中相关性肺炎的Meta分析

摘要

Objective To systematic evaluate the curative effect of adjuvant therapy of TCM on stroke-associated pneumonia. Methods Databases including CBM, VIP, WanFang data, CNKI, and PubMed were electronically searched from January 2000 to July 2015, to identify randomized controlled trials (RCTs) of TCM on stroke-associated pneumonia. The papers were screened according to the inclusion and exclusion criteria, the data were extracted, the curative effect and pyretolysis time was meta-analysis by using Review Manger 5.2 software. Results A total of 14 RCTs (including 1185 cases) papers on TCM for treatment of stroke-associated pneumonia were obtained, and therapeutic evaluation were adopted in 14 studies, while pyretolysis time were observed in 9 studies. The Meta analysis showed that the curative effect of stroke-associated pneumonia combined with TCM was superior to that of conventional therapy with Western medicine (Z=7.36, P<0.000 01), and the pyretolysis time was less (Z=3.48,P<0.01). Funnel chart shows that there is publication bias. Conclusion The curative effect and pyretolysis time of stroke-associated pneumonia combined with TCM was superior to that of control group, which needs high-quality papers to verify support.%目的 对中医药辅助治疗卒中相关性肺炎进行系统评价.方法 计算机检索CBM、VIP、WF、CNKI、PubMed数据库,查找关于卒中相关性肺炎应用中医药的随机对照实验(RCTs),时限检索均从2000年1月至2015年7月.按文献纳入与排除标准筛选文献,提取所需资料并利用Review Manger5.2分析软件对总有效率和热退时间进行Meta分析.结果 最终得到14篇关于中医药辅助治疗卒中相关性肺炎的RCTs文献,共计1 185例患者,其中有14项研究进行了疗效评价,9项研究观察了热退时间.经Meta分析发现,对于卒中相关性肺炎患者,同时配合应用中医药的总有效率优于西医常规治疗(Z=7.36,P<0.000 01),且可缩短体温恢复至正常时间(Z=3.48,P<0.01),漏斗图显示存在发表偏倚.结论 同时配合应用中医药辅助治疗卒中相关性肺炎在总有效率、热退时间优于对照组,但需要高质量的文献来验证支持.