不同促渗剂对雷公藤红素醇质体体外透皮吸收的研究

摘要

以离体小鼠皮肤为屏障，采用 TP2A 型智能透皮试验仪进行体外透皮试验，用 HPLC 法测定不同促渗剂对雷公藤红素醇质体的累积渗透量和渗透速率的影响。研究发现，不同促渗剂对雷公藤红素醇质体的累积渗透量和渗透速率的影响大小依次为：丙二醇＞氮酮＞甘油＞薄荷脑，而15％丙二醇的促渗效果最佳，可以作为雷公藤红素醇质体的最佳促渗剂。%The paper studied the effects of several kinds of penetration enhancers on percutaneous absorp-tion of Celastrol ethosomes in vitro.TP2A-type intelligent transdermal test instrument was adopted as the apparatus for in vitro mouse skin permeation.The cumulative permeation quantity and penetration rate of different penetration enhancers on Celastrol ethosomes waere determined by HPLC.Results shuggest tha the ordering of the effects of penetration enhancers was propylene glycol > azone > glycerol > menthol. The effect of 15% propylene glycol was the most influencing enhancer.The conclusion can be arrived at that 15% propylene glycol can be the best penetration enhancers for Celastrol ethosomes.