邻香草醛缩4-氯邻氨基苯酚Schiff碱正丁基锡配合物的合成、晶体结构及生物活性研究

摘要

利用邻香草醛缩4-氯邻氨基苯酚 Schiff碱(H2 L)和正丁基三氯化锡反应，合成了一个 Schiff碱正丁基锡配合物(C1)，通过元素分析、FT-IR、1 H NMR、13 C NMR以及 X-射线单晶衍射对合成的有机锡 Schiff碱配合物C1进行了表征。研究了配合物(C1)的紫外可见光谱，并且运用 MTT 方法，研究了该有机锡 Schiff碱配合物对癌细胞的体外抑制活性，研究的结果显示，该有机锡 Schiff 碱配合物 C1对 MCF7、NCI-H460的抑制活性相比卡铂要更优越，因而可以考虑经过化学优化后，作为抗癌药物的备选化合物。%Schiff base organotin(IV)complex C1 has been synthesized via the reaction of the o-vanillin-4-chloride-2-aminophenol Schiff base (H2 L)with the butyltin trichloride.The complex has been characterized by IR,1 H NMR,13 C NMR spectra,elemen-tal analysis and X-ray diffraction.The UV-vis spectra of the complex was determined.The anticancer activity of the Schiff base ligand (H2 L)and complex C1 against five species of cancer cell which are Hela,MCF7,HepG2,Colo205,NCI-H460 were tested respectively,and the tests showed that the complex was more active than carboplatin against tested MCF7,NCI-H460 cancer cell lines and has a potential application of drug preparation.