Objective Discuss the correlationg between the levels of serum neuron-specific enolase ( NSE) and the risk of hemorrhagic transformation( HT) of acute cerebral without thrombolysis. Method 96 cases whose admission time <72 hours was selected in accordance with the WHO criteria for the di-agnosis of cerebral infarction, and head CT ruled out bleeding in patients with acute infarction. After 7 to 10 days after the review of magnetic resonance imaging ( MRI) gradient echo sequence showed low signal for hemorrhagic transformation. The level of NSE was detectioned by Elisa, and we also stuied the corre-lation between NSE and HT. Results 36 of 96 pations come to hemorrhagic transformation, other 60 pa-tions were no transformaion group. The NSE levels was higher in hemorrhagic transformation group than no transformation group, and the differences were significant (P<0. 05). Factors affecting the hemor-rhagic transformation included by history of atrial fibrillation, hypertension, low density lipoprotein cho-lesterol ( hdl-c ) and NSE level ( P<0 . 05 ) . Logistic stepwise polynomial regression analisis indicated that serum NSE level and atrial fibrillation were risk factors for hemorrhage transformation. Conclusion Testing the level of NSE was relationship with the risk of HT in actue cerebral infavction patients in the early stage, and this could be the independent risk factor of HT.%目的：探讨未进行溶栓的急性脑梗死患者血浆神经烯醇化酶( NSE)水平与出血性转化的相关性。方法选择96例入院时间<72 h,符合WHO脑梗死诊断标准,且头部CT排除出血的急性脑梗死患者,发病7~10 d后复查MRI梯度回波序列显示低信号为出血性转化；Elisa法定量检测血浆NSE水平；并探讨其与出血性转化的相关性。结果96例患者中36例出现出血性转化(转化组),其余60例为非转化组,出血性转化脑梗死组神经烯醇化酶水平高于非出血性转化组,差异有统计学意义(P<0.05),相关危险因素的单因素分析显示房颤、高血压病史、低密度脂蛋白、NSE均影响出血性转化水平(P<0.05)。多因素Logistic回归分析显示,血浆神经烯醇化酶水平及房颤为出血性转化的危险因素(P<0.05)。结论急性脑梗死患者早期测定神经烯醇化酶水平与其出血性转化相关,这可能是出血性转化的独立危险因素。
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