Measurement of Local Blood Flow and Oxygen Consumption in Evolving Irreversible Cerebral Infarction: An in Vivo Study in Man

摘要

Positron emission tomography (PET) allows in vivo measurement of local cerebral blood flow (1CBF), oxygen consumption rate (1CMRO sub 2 ) and glucose utilisation (1CMRG1c) in man. Although 1CMRG1c is accessible in animals, this is not the case for 1CMRO sub 2 , an excellent index of local functional state. PET imaging of the local interrelationship of CBF and metabolism in completed ischemic stroke has attracted considerable interest because of its potential to differentiate irreversibly damaged from viable tissue on the basis of the CBF- metabolism patterns. Several qualitative or semi-quantitative pioneering studies provided a limited insight into this question, while the single truly quantitative study was only briefly reported. We report here a detailed study of the local CBF-CMRO sub 2 quantitative patterns in irreversibly infarcted brain regions. (Atomindex citation 14:742341)