目的：通过对股骨肿瘤患者的回顾性调查，分析其性别、年龄、部位分布特点。方法通过病案查询系统，收集1980年1月—2012年12月资料完整经过手术治疗且有明确病理结果的股骨肿瘤病例，对其性别、年龄、部位分布及类型构成比进行统计学分析，并得出原发性股骨肿瘤性质的独立影响因素。结果共采集股骨肿瘤1504例，其中原发性股骨肿瘤1385例，转移瘤119例，原发性股骨肿瘤高发类型为良性肿瘤，高发部位为股骨远端，高发年龄段为＞10～20岁。良性、恶性高发年龄段均为＞10～20岁，中间型高发年龄段为＞20～30岁。原发股骨恶性肿瘤和转移瘤部位、年龄分布比较差异均有统计学意义（χ2＝226．976，P ＜0．01；χ2＝215．204，P ＜0．01）。有序 Logistic 回归分析显示性别、年龄、部位均是原发性股骨肿瘤性质的独立影响因素（P ＜0．05）。结论原发性股骨肿瘤男性多于女性，多见＞10～20岁，骨肉瘤是最常见的恶性股骨肿瘤，原发性恶性股骨肿瘤主要发生在股骨远端，转移瘤主要发生在股骨近端，性别、年龄、部位均为原发股骨肿瘤性质的独立危险因素，对于45岁以上的女性股骨远端的占位病变临床医生应该引起高度重视。%ABSTRACT:Objective To analyze the characteristics of femoral tumor cases on sex,age and site through the retrospective study of femoral tumor in our hospital.Methods Through our hospital medical record inquiry system,the femoral tumor cases who had integrity data after operation and had a clear pathological diagnosis of tumor from 1980 January to 2012 December were collected.The sex,age,site and type of constituent ratio were statistically analyzed and the independent risk factors of primary bone malignancy were got.Results One thousand five hundred and four femoral tumor cases were collected,including 1385 cases of primary bone tumors,119 cases of metastatic tumors.Primary bone tumors in high incidence of type of benign tumor,high risk sites were distal femur,the high age of >10- 20 years old.Benign,malignant high risk age was > 10 - 20,intermediate type high risk age ranged > 20 - 30 years old.There were significant differences on the site and age distribution of the primary femoral malignant tumor and metastasis tumor (χ2 = 226.976,P < 0.01;χ2 = 215.204,P < 0.01 ).The logistic regression analysis showed sex,age,and site were independent risk factors of primary bone tumor on malignant degree (P <0.05).Conclusion There were more males than females in the primary bone tumor cases.The highest-risk age group for both sexes was > 10 - 20 years.The most common malignancy of the primary femoral tumor was osteosarcoma.The primary malignant bone tumor mainly occurred in the distal femur and metastases mainly occurred in the proximal femur.The sex,age and site were independent risk factors on malignant degree.Clinicians should pay more attention to females over the age of 45 years old who had space occupying lesions in the distal femur.
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