Objective:To observe the effect of tirofiban combined with clopidogrel on serum inflammatory factors and coagulation functions in patients with acute myocardial infarction (AMI).Methods:A total of 106 patients with AMI were se-lected and randomly divided into observation group (55 cases)and control group (5 1 cases).The control group was given clopi-dogrel based on conventional therapy,and the observation was given tirofiban based on the control group.For 2 weeks,the changes of serum inflammatory factors (TNF-α,hs-CRP,IL-6,P-selection)and coagulation functions (PT,TT,APTT)be-tween the two groups were observed.Results:After treatment,TNF-α,hs-CRP,L-6 and P-selection levels in the two group both decreased compared with that before treatment (P <0.05),TNF-α,hs-CRP,L-6 and P-selection levels in the observation group were decreased more significantly than that in the control group (P <0.05).After treatment,PT,TT and APTT levels in the two group both extended compared with that before treatment (P <0.05),PT,TT and APTT levels in the observation group were improved more significantly than that in the control group (P <0.05 ).There was no significant difference in ad-verse reactions between the two groups (P <0.05).Conclusions:Tirofiban combined with clopidogrel could restrain inflamma-tory response and regulate coagulation functions more significant in patients with AMI,and better than that of using clopi-dogrel alone.%目的：：观察替罗非班联合氯吡格雷对急性心肌梗死(AMI)患者血清炎症因子及凝血功能的影响.方法：106例 AMI 病例随机分为观察组(55例)和对照组(51例).对照组在常规治疗的基础上给予氯吡格雷,观察组在对照组的基础上给予替罗非班.治疗2周,观察两组炎症因子(TNF-α、hs-CRP、IL-6、P-selectin)及凝血功能(PT、TT、APTT)的变化.结果：(1)治疗后,两组 TNF-α、hs-CRP、IL-6及P-selectin 均明显下降(P ＜0．05),且观察组治疗后 TNF-α、hs-CRP、IL-6及 P-selectin 水平分别为(2．75±1．53)ng/L、(2．23±1．48)mg/L、(6．34±2．25)ng/mL、(8．21±2．45)ng/mL,均显著低于对照组治疗后,同期比较差异有统计学意义(P ＜0．05)；(2)治疗后,两组 PT、APTT、TT 较明显延长(P ＜0．05),且观察组治疗后 PT、TT、APTT 分别为(14．35±1．68)s、(27．21±4．13)s、(26．32±3．19)s,显著大于对照组治疗后,同期比较差异有统计学意义(P ＜0．05)；(3)两组不良反应无明显差异(P ＞0．05).结论：替罗非班联合氯吡格雷应用于 AMI 时抑制炎症反应、调节凝血功能作用更为显著,优于单用氯吡格雷.
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