丁苯酞联合阿托伐他汀对急性脑梗死患者血清 NSE、ANG I I、Hcy、炎性因子及凝血功能指标水平的影响

摘要

Objective:To observe the effect of butylphthalide combined with atorvastatin of atorvastatin on serum NSE, ANG II,Hcy inflammatory factors and coagulation function indexes in patients with acute cerebral infarction.Methods:A total of 74 patients with acute cerebral infarction in our hospital from January 201 5 to December 201 5 were randomly divided into the observation group and the control group,with 37 cases in each group.The control group was given conventional treatment,the observation group was given the butylphthalide soft capsules 0.2 g on the basis of the control group'treatment scheme orally 3 times a day,atorvastatin calcium tablets 80 mg orally once a day.The changes of serum ANG,NSE I,Hcy,inflammatory fac-tor and blood coagulation function index in the two groups before and after treatment were compared.Results:There was no significant difference in the levels of NSE,II ANG and Hcy before treatment(P >0.05),all decreased after treatment.The lev-els of NSE,Ang II,Hcy in the observation group were respectively significantly lower than that in control group (P <0.05);There were no significant differences in CRP,IL-6 and IL-10 between the two groups before treatment (P >0.05).After treat-ment,the levels of inflammatory markers in the two groups after treatment were significantly lower than those in the same group before treatment (P <0.05);After treatment,CRP,IL-6,IL-10 of observation group were significantly lower than that in control group (P <0.05 ).There were no significant differences in APTT,FIB,PT,TT between the two groups before treatment (P > 0.05 ).After treatment,the APTT,PT,TT in observation group was significantly higher than the control group (P <0.05),while FIB was significantly lower than the control group (P <0.05).Conclusions:Butylphthalide combined with atorvastatin of atorvastatin has good curative effect on patients with acute cerebral infarction.It can reduce the serum NSE,AngII,Hcy,inflammatory factors,content and prolong the clotting time,so as to improve the clinical symptoms and prognosis of'patients.%目的：：观察丁苯酞联合阿托伐他汀对急性脑梗死患者血清 NSE、ANG II、Hcy、炎性因子及凝血功能指标水平的影响.方法：选择2015年1月~2015年12月至陕西汉中3201医院进行急性脑梗死治疗的患者74例,随机分为观察组与对照组各37例.对照组进行常规治疗,观察组在对照组治疗基础上给予丁苯酞软胶囊0．2 g,3次/d,口服.阿托伐他汀钙片80 mg,1次/d,口服.观察两组患者治疗前后血清 NSE、ANG II、Hcy、炎性因子及凝血功能指标水平变化.结果：两组患者治疗前 NSE、ANG II、Hcy 无明显差异(P ＞0．05),治疗后均有所降低,观察组的 NSE、ANG II、Hcy 分别为(13．54±3．88)μg/L、(38．44±6．49)pg/mL、(12．06±1．38)mmol/L,明显低于对照组(P ＜0．05).两组患者治疗前CRP、IL-6、IL-10无明显差异(P ＞0．05),治疗后两组患者各炎性指标水平显著低于同组治疗前(P ＜0．05)；治疗后观察组 CRP、IL-6、IL-10明显低于对照组治疗后的 CRP、IL-6、IL-10(P ＜0．05).两组患者治疗前 APTT、FIB、PT、TT 无明显差异,治疗后观察组 APTT、PT、TT 明显高于对照组(P ＜0．05),而观察组 FIB 为(2．52±0．31)g/L,明显低于对照组的(3．94±0．82)g/L(P ＜0．05).结论：丁苯酞联合阿托伐他汀对急性脑梗死患者具有很好的治疗疗效,能够降低血清 NSE、ANG II、Hcy、炎性因子的含量,延长凝血时间,从而改善患者临床症状.