利拉鲁肽治疗老年2型糖尿病患者对血管内皮功能及胰岛β细胞功能的影响

摘要

目的：：探讨利拉鲁肽治疗老年2型糖尿病(T2DM)患者对血管内皮功能及胰岛β细胞功能的影响.方法：选择100例老年2型糖尿病患者,随机分为观察组与对照组各50例,对照组根据患者血糖水平给予盐酸二甲双胍联合格列美脲常规治疗,观察组在常规治疗的基础上给予利拉鲁肽治疗,观察两组治疗1个月、3个月血管内皮功能及胰岛β细胞功能改善情况.结果：(1)两组治疗前 ET-1、NO、FMD水平比较,差异无统计学意义(P ＞0．05)；治疗1个月、3个月观察组较治疗前 NO、FMD 增高,ET-1降低,且观察组 NO、FMD 水平明显高于对照组,且 ET-1水平低于对照组,差异有统计学差异(P ＜0．05)；(2)两组治疗前 FPG、2 h PBG、HbA1c 水平比较,差异无统计学意义(P ＞0．05)；治疗后1个月、3个月观察组 FPG、2 hPBG、HbA1c 水平明显低于对照组,差异有统计学意义(P ＜0．05)；(3)两组治疗前FIns、HOMA-IR、HOMA-B 水平比较,差异无统计学意义(P ＞0．05)；治疗1个月、3个月观察组 FIns、HOMA-B 水平增高、HOMA-IR 降低,且观察组 FIns、HOMA-B 水平高于对照组,HOMA-IR 明显低于对照组,差异有统计学意义(P ＜0．05).结论：利拉鲁肽治疗老年 T2DM 患者可有效其改善血管内皮功能及胰岛β细胞功能.%Objective:To observe the effects of liraglutide treatment on vascular endothelial function and pancreatic βcell function in elderly patients with type 2 diabetes mellitus (T2DM).Methods:A total of 100 cases of elderly patients with type 2 diabetes mellitus were selected and randomly divided into observation group and control group with 50 cases in each group,the control group received conventional therapy of metformin hydrochloride combining with glimepiride based on blood glucose levels,the observation group was given liraglutide treatment on the basis of conventional treatment.The improvements of endothelial function and pancreatic β-cell function in two groups were observed for 1 month and 3 months.Results:1.The levels of ET-1,NO and FMD in both groups were not statistically significant before treatment (P >0.05).After treatment for 1 month and 3 months,the levels of NO and FMD in the observation group increased and were higher than that in the control group,but the level of ET-1 in the observation group decreased and was lower than that in the control group (P all <0.05);2. The levels of FPG,2hPBG and HbA1c in both groups were not statistically significant before treatment (P > 0.05 ).After treatment for 1 month and 3 months,the levels of FPG,2 hPBG and HbA1c in the observation group were significantly lower than that in the control group (P <0.05);3.The levels of FIns,HOMA-IR and HOMA-B in both groups were not statistically significant before treatment (P >0.05).After treatment for 1 month and 3 months,the levels of FIns and HOMA-B in the ob-servation group increased and were significantly higher than that in the control group,the level of HOMA-IR in the observation group decreased and was significantly lower than that in the control group (P all<0.05).Conclusion:Liraglutide treatment can effectively improve endothelial function and isletβcell function in elderly patients with T2DM.