金水宝胶囊辅助治疗对糖尿病肾病患者血清炎性因子、氧化应激及肾功能的影响

摘要

目的:探讨金水宝胶囊辅助治疗糖尿病肾病,对患者血清炎性因子、氧化应激及肾功能的影响.方法:依据随机数据表法124例糖尿病肾病患者分为对照组和观察组,每组62例,两组均给予常规治疗,在此基础上,对照组给予缬沙坦胶囊治疗,观察组给予缬沙坦胶囊联合金水宝胶囊治疗.比较治疗前后,两组血压[收缩压(SBP),舒张压(DBP)]、炎性因子[肿瘤坏死因子-α(TNF-α),超敏C反应蛋白(hs-CRP)]、氧化应激[超氧化物歧化酶(SOD),丙二醛(MDA)]以及肾功能相关指标[血肌酐(Scr),尿素氮(BUN)]水平.结果:两组治疗前SBP、DBP、TNF-α、hs-CRP、SOD、MDA、Scr及BUN水平比较相近,差异比较无统计学意义(P>00.5).观察组治疗后SBP、DBP、TNF-α、hs-CRP、MDA、Scr及BUN水平均显著低于治疗前观察组水平,且观察组治疗后TNF-α、hs-CRP、MDA、Scr及BUN显著低于对照组治疗后水平,差异有统计学意义(P<00.5);与组内治疗前相比,两组SOD水平均显著升高,且观察组显著高于对照组,差异有统计学意义(P<00.5).结论:金水宝胶囊辅助治疗糖尿病肾病,减轻慢性炎症及氧化应激状态,改善肾功能,具有重要临床价值.%Objective:To investigate the effect of Paecilomyces hepiall chen on serum inflammatory factors ,oxidative stress and renal function in patients with diabetic nephropathy .Methods:A total of 124 cases of diabetic nephropathy patients were selected as the research object ,based on the random data table they were divided into the control group and the observa-tion group ,62 cases in each group ,two groups of patients were given conventional treatment ,on this basis ,the patients in the control group were treated with Valsartan Capsules treatment ,while patients in the observation group were given Valsartan Capsules combined with Paecilomyces hepiall chen treatment .To compare the levels of blood pressure [systolic blood pressure(SBP) ,diastolic blood pressure (DBP)] ,inflammatory factor [tumor necrosis factor-α (TNF-α) ,high sensitive C reactive protein (hs-CRP)] ,oxidative stress[superoxide dismutase (SOD) ,malondialdehyde (MDA)] and renal function index[serum creatinine (Scr) ,urea nitrogen (BUN)] of the two groups before and after treatment .Results:Before treatment ,there were no significantly different of the levels of SBP ,DBP ,TNF-α,hs-CRP ,SOD ,MDA ,Scr and BUN between the two groups .After treatment ,the observation group SBP ,DBP ,TNF-α,hs-CRP ,MDA ,Scr and BUN level were (135 .71 ± 15 .64) mmHg , (849.6 ± 139.7) mmHg ,(463.7 ± 59.2) ng/L ,(59.9 ± 09.4) mg/L ,(209.1 ± 23.8)μmol/L ,(838.6 ± 101.6)μmol/L and (65.3 ± 13.7) mmol/L ,were significantly lower than before treatment ,and after treatment the TNF-α,hs-CRP ,MDA ,Scr and BUN in observation group were significantly lower than the control group (P<00.5);Compared with the levels in the same group before treatment ,the two groups of SOD levels were significantly increased ,and the observation group [(93 .21 ± 70.6) U/mL] was significantly higher than the control group[(798.4 ± 61.2)U/mL] (P<00.5) .Conclusion:Paecilomyces hepiall chen on treatment of diabetic nephropathy ,can effectively relieve chronic inflammation and oxidative stress ,improve renal function , has an important clinical value .