Covered by CAS, CSA, IC, CAB Abstract, Global Health, Chinese Scientific Core Journal, Chinese Scientific Journal Effect of paecilomyces hepiall chen on serum inflammatory factors, oxidative stress and renal function in patients with diabetic nephropathy

摘要

Objective: To investigate the effect of paecilomyces hepiall chen on serum inflammatoryfactors, oxidative stress and renal function in patients with diabetic nephropathy. Methods: Atotal of 124 cases of diabetic nephropathy patients were selected as the research object, basedon the random data table they were divided into the control group and the observation group,62 cases in each group, two groups of patients were given conventional treatment, on thisbasis, the patients in the control group were treated with valsartan capsules treatment, whilepatients in the observation group were given valsartan capsules combined with paecilomyceshepiall chen treatment. To compare the levels of blood pressure [systolic blood pressure (SBP),diastolic blood pressure (DBP)], inflammatory factor [tumor necrosis factor -α (TNF-α),high sensitive C reactive protein (hs-CRP)], oxidative stress [superoxide dismutase (SOD),malondialdehyde (MDA)] and renal function index [serum creatinine (Scr), urea nitrogen(BUN)] of the two groups before and after treatment. Results: Before treatment, there were nosignificantly different of the levels of SBP, DBP, TNF-α, hs-CRP, SOD, MDA, Scr and BUNbetween the two groups. After treatment, the observation group SBP, DBP, TNF-α, hs-CRP,MDA, Scr and BUN level were (135.71±15.64) mmHg, (84.96±13.97) mmHg, (46.37±5.92)ng/L, (5.99±0.94) mg/L, (20.91±2.38) μmol/L, (83.86±10.16) μmol/L and (6.53±1.37) mmol/L, were significantly lower than before treatment, and after treatment the TNF-α, hs-CRP,MDA, Scr and BUN in observation group were significantly lower than the control group;Compared with the levels in the same group before treatment, the two groups of SOD levelswere significantly increased, and the observation group [(93.21±7.06) U/mL] was significantlyhigher than the control group [(79.84±6.12) U/mL]. Conclusion: Paecilomyces hepiall chen ontreatment of diabetic nephropathy, can effectively relieve chronic inflammation and oxidativestress, improve renal function, has an important clinical value.