血清PCT含量对重症急性胰腺炎患者炎症反应、RAS激活程度的评估价值

摘要

Objective: To study the value of serum PClevelfoassessing the inflammatory response and RAactivation degree in patientwith severe acute pancreatitis.Methods: total of 76 patientwith acute pancreatitiwho were treated in ouhospital between May 2013 and April 2016 were collected, and 50 patientwith pure diarrhewho received infusion treatmenin ouhospital during the same period were selected athe control group.Serum PClevelof both groupwere detected, and the observation group were furthedivided into high PCgroup and low PCgroup (n=38) according to the median of PClevels.Enzyme-linked immune-sorbenassay (ELISA) waused to determine serum levelof pro-inflammatory factors, anti-inflammatory factorand RAindexes.Results: Serum PClevel of observation group wahighethan thaof control group (P<0.05);serum pro-inflammatory factorIL-1β, IL-6, CRP and TNF-α levelof high PCgroup and low PCgroup were highethan those of control group, anti-inflammatory factorIL-4, IL-10 and IL-13 levelwere highethan those of control group, and RAindexeAngⅡ, Rand ALD levelwere highethan those of control group (P<0.05);serum pro-inflammatory factorIL-1β, IL-6, CRP and TNF-α levelof high PCgroup were highethan those of low PCgroup, anti-inflammatory factorIL-4, IL-10 and IL-13 levelwere highethan those of low PCgroup, and the RAindexeAngⅡ, Rand ALD levelwere highethan those of low PCgroup (P<0.05).Conclusions: The serum PClevelcan assesthe inflammatory response and RAactivation degree in the patientwith severe acute pancreatitis.%目的:探讨血清PCT含量对重症急性胰腺炎患者炎症反应、RAS激活程度的评估价值.方法:收集在本院接受治疗的急性胰腺炎患者76例,另取同期在本院接受输液治疗的单纯腹泻患者50例作为对照组.检测两组患者血清PCT含量,根据观察组PCT含量中位数进一步分为高PCT组、低PCT组各38例.采用酶联免疫吸附法(ELISA)测定血清促炎因子、抗炎因子及RAS指标含量.结果:观察组血清PCT含量高于对照组患者(P<0.05);高PCT组、低PCT组血清中促炎因子IL-1β、IL-6、CRP、TNF-α含量高于对照组,抗炎因子IL-4、IL-10、IL-13含量高于对照组,RAS指标AngⅡ、RA、ALD含量高于对照组(P<0.05);高PCT组血清中促炎因子IL-1β、IL-6、CRP、TNF-α含量高于低PCT组,抗炎因子IL-4、IL-10、IL-13含量高于低PCT组,RAS指标AngⅡ、RA、ALD含量高于低PCT组(P<0.05).结论:血清PCT含量能够评估重症急性胰腺炎患者的炎症反应程度、RAS激活程度.