The value of serum PCT levels for assessing the inflammatory response and RAS activation degree in patients with severe acute pancreatitis

摘要

Objective: To study the value of serum PCT levels for assessing the inflammatory responseand RAS activation degree in patients with severe acute pancreatitis. Methods: A total of 76patients with acute pancreatitis who were treated in our hospital between May 2013 and April2016 were collected, and 50 patients with pure diarrhea who received infusion treatment inour hospital during the same period were selected as the control group. Serum PCT levelsof both groups were detected, and the observation group were further divided into high PCTgroup and low PCT group (n=38) according to the median of PCT levels. Enzyme-linkedimmunosorbent assay (ELISA) was used to determine serum levels of pro-inflammatoryfactors, anti-inflammatory factors and RAS indexes. Results: Serum PCT level of observationgroup was higher than that of control group; serum pro-inflammatory factors IL-1β, IL-6,CRP and TNF-α levels of high PCT group and low PCT group were higher than those ofcontrol group, anti-inflammatory factors IL-4, IL-10 and IL-13 levels were higher than those ofcontrol group, and RAS indexes AngⅡ, RA and ALD levels were higher than those of controlgroup; serum pro-inflammatory factors IL-1β, IL-6, CRP and TNF-α levels of high PCTgroup were higher than those of low PCT group, anti-inflammatory factors IL-4, IL-10 andIL-13 levels were higher than those of low PCT group, and the RAS indexes AngⅡ, RA andALD levels were higher than those of low PCT group. Conclusion: The serum PCT levels canassess the inflammatory response and RAS activation degree in the patients with severe acutepancreatitis.