血清PCT水平对68例全身炎症反应综合征患儿预后评估的价值

摘要

Objective:To investigate the clinical signiifcance of serum procalcitonin (PCT) levels in the assessment of the systemic inlfammatory response syndrome (SIRS) in children.Methods: Sixty-eight cases of children with SIRS were selected by a prospective case-control method and divided into a sepsis group and a non-sepsis group based on their exact infection. The levels of serum PCT were detected within 24 h after admission and pediatric critical illness (PCIS) score was performed. The survival of SIRS children in 28 days of hospitalization was assessed and they were divided into a death group and a survival group according to their clinical outcome and the relationship of serum PCT levels with PCIS score was analyzed by Spearman correlation analysis.Results:The serum PCT levels at admission were signiifcantly higher in the sepsis group than in the non-sepsis group while PCIS score was signiifcantly lower in the sepsis group (P<0.05). The levels of serum PCT were signiifcantly higher in the death group than in the survival group while PCIS score was signiifcantly lower in the death group (P<0.05). The serum PCT levels showed a signiifcant negative correlation with PCIS score (r=-0.637,P<0.01).Conclusion:The monitoring of serum PCT levels in SIRS children is of beneift to early diagnosis of sepsis and non-sepsis and they can be used as important indexes for the assessment of the prognosis of SIRS children.%目的：探讨血清降钙素原（PCT）水平对全身炎症反应综合征（SIRS）患儿病情预后评估的临床意义。方法：采用前瞻性病例对照方法，选取68例确诊的SIRS患儿分为脓毒症组和非脓毒症组，入院后24 h内检测血清PCT水平，作小儿危重病例（PCIS）评分；评估SIRS患儿住院28 d内生存情况，根据患儿临床结局分为死亡组和存活组，采用Spearman法分析患儿血清PCT水平与PCIS评分的关系。结果：脓毒症组入院时的血清PCT水平明显高于非脓毒症组，而PCIS评分明显低于非脓毒症组患儿（P<0.05）；死亡组患儿血清PCT水平明显高于存活组患儿，PCIS评分明显低于存活组患儿（P<0.05）；血清PCT水平与PCIS评分呈显著负相关（r=-0.637, P<0.01）。结论：对SIRS患儿进行血清PCT水平监测，可有助于早期判断脓毒症和非脓毒症，可作为评估SIRS患儿病情预后的重要指标。