CTX+5-FU+DDP支气管动脉化疗栓塞对IIIa-IIIb期NSCLC恶性程度的影响

摘要

Objective:To investigate the effect of CTX+5-FU+DDP transbronchial arterial chemoembolization on malignant degree of IIIa-IIIb NSCLC.Methods:88 patients with IIIa-IIIb NSCLC treated in our hospital between June 2012 and October 2015 were collected and divided into observation group and control group (n=44) according to random number table.Control group of patients received conventional CFP intravenous chemotherapy and the observation group of patients received CTX+5-FU+DDP transbronchial arterial chemoembolization.Before and after treatment,ELISA was used to detect the serum tumor marker levels;fluorescence quantitative PCR (RT-PCR) was used to detect proliferation and invasion gene mRNA expression in tumor tissue.Results:After treatment,serum CA19-9,NSE,CYFRA21-1 and TK1 levels of observation group were significantly lower than those of control group (P<0.05);HOXB7,COPDS3,TEM8,PAK4 and LIMK1 mRNA expression in tumor tissue of observation group were significantly lower than those of control group while LRRC3B,TCF21,LASS2,TMSG-1 and cofilin mRNA expression were significantly higher than those of control group (P<0.05).Conclusion:CTX+5-FU+DDP transbronchial arterial chemoembolization can decrease the tumor malignancy of patients with IIIa-IIIb NSCLC.%目的:探讨CTX+5-FU+DDP支气管动脉化疗栓塞对IIIa-IIIb期NSCLC恶性程度的影响.方法:收集本院收治的IIIa-IIIb期NSCLC患者88例,按照随机数表法分为观察组、对照组各44例.对照组接受常规CFP静脉化疗,观察组接受CTX+5-FU+DDP支气管动脉化疗栓塞.治疗前和治疗后,采用ELISA法检测血清肿瘤标志物含量;采用荧光定量PCR(RT-PCR)法检测肿瘤组织中增殖、侵袭基因的mRNA表达量.结果:治疗后,观察组血清中CA19-9、NSE、CYFRA21-1、TK1的含量均显著低于对照组(P<0.05);观察组肿瘤组织中HOXB7、COPDS3、TEM8、PAK4、LIMK1的mRNA表达量均显著低于对照组,LRRC3B、TCF21、LASS2、TMSG-1、cofilin的mRNA表达量均显著高于对照组(P<0.05).结论:CTX+5-FU+DDP支气管动脉化疗栓塞可降低IIIa-IIIb期NSCLC患者的肿瘤恶性程度.