Effect of CTX+5-FU+DDP transbronchial arterial chemoembolization on malignant degree of IIIa-IIIb NSCLC

摘要

Objective: To investigate the effect of CTX+5-FU+DDP transbronchial arterialchemoembolization on malignant degree of IIIa-IIIb NSCLC. Methods: A total of 88 patientswith IIIa-IIIb NSCLC treated in our hospital between June 2012 and October 2015 werecollected and divided into observation group and control group (n=44) according to randomnumber table. Control group of patients received conventional CFP intravenous chemotherapyand the observation group of patients received CTX+5-FU+DDP transbronchial arterialchemoembolization. Before and after treatment, ELISA was used to detect the serum tumormarker levels; fluorescence quantitative PCR (RT-PCR) was used to detect proliferation andinvasion gene mRNA expression in tumor tissue. Results: After treatment, serum CA19-9,NSE, CYFRA21-1 and TK1 levels of observation group were significantly lower thanthose of control group; HOXB7, COPDS3, TEM8, PAK4 and LIMK1 mRNA expressionin tumor tissue of observation group were significantly lower than those of control groupwhile LRRC3B, TCF21, LASS2, TMSG-1 and cofilin mRNA expression were significantlyhigher than those of control group. Conclusion: CTX+5-FU+DDP transbronchial arterialchemoembolization can decrease the tumor malignancy of patients with IIIa-IIIb NSCLC.