尼可地尔对CSF患者冠状动脉微循环及血流动力学的影响

摘要

Objective: To explore the effect of nicorandil on the coronary artery microcirculation and hemodynamics in patients with coronary slow flow (CSF).Methods: A total of 86 patients with CSF who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 43 cases in each group.The patients in the control group were given aspirin, HMG-CoA reductase inhibitor, and ACEI.On this basis, the patients in the treatment group were given nicorandil.The patients in the two groups were continuously treated for 6 months.The coronary artery microcirculation and hemodynamic indicators before and after treatment in the two groups were detected and compared.Results: TAT, ET-1, and hs-CRP levels, LAD, LCX, RCA, TIMI average blood flow frame count value, and IMR after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05).The above indicators after treatment in the treatment group were significantly lower than those in the control group (P<0.05).FMD after treatment in the two groups was significantly elevated when compared with before treatment (P<0.05).FMD after treatment in the treatment group was significantly higher than that in the control group (P<0.05).Conclusions: Nicorandil in the treatment of CSF can effectively improve the coronary artery microcirculation and hemodynamics, with a significant efficacy.%目的:探讨尼可地尔对冠状动脉慢血流(CSF)患者冠状动脉微循环和血流动力学的影响.方法:选取南京中医药大学附属江阴医院收治的CSF患者86例,随机分为对照组与治疗组,各43例.对照组采用阿司匹林、羟甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂和血管紧张素转换酶抑制剂(ACEI)治疗,治疗组在对照组治疗基础上加用尼可地尔治疗,2组均连续治疗6个月;检测并比较治疗前后2组患者冠状动脉微循环及血流动力学指标的变化.结果:治疗后2组TAT、ET-1及hs-CRP水平,LAD、LCX、RCA、TIMI血流帧数平均值及IMR均较治疗前显著降低(P<0.05);治疗组治疗后上述指标均显著低于对照组(P<0.05);2组治疗后FMD较治疗前显著升高(P<0.05);治疗组治疗后FMD显著高于对照组(P<0.05).结论:尼可地尔可有效改善CSF患者冠状动脉微循环和血流动力学,疗效显著.