冠心病患者三维斑点追踪参数与左心室重构过程中血清指标变化的相关性

摘要

Objective :To study the correlation between three-dimensional speckle tracking parameters and serum index changes during left ventricular remodeling in patients with coronary heart disease .Methods :Patients who were diagnosed with coronary heart disease and angina pectoris in our hospital between March 2015 and May 2017 were selected as the CHD group of the study ,and the healthy subjects who received medical examination in our hospital during the same period were taken as the control group ;the three-dimensional speckle tracking parameters ,peripheral blood signal molecule expression as well as se-rum cytokine and collagen metabolism index levels of the two groups were measured .Results :GLS and AGS levels in CHD group were significantly lower than those in control group whereas GCS and GRS levels were not significantly different from those in control group ,and peripheral blood Notch1 ,Hes1 ,NF-κB and PKC expression intensity as well as serum sTWEAK , FGF23 ,TGF-β1 ,GDF15 ,sSema4D ,CaN ,MMP14 ,PINP and ICTP contents were significantly higher than those of control group ;GLS and AGS levels in CHD group were negatively correlated with peripheral blood Notch 1 ,Hes1 ,NF-κB and PKC expression intensity as well as serum sTWEAK ,FGF23 ,TGF-β1 ,GDF15 ,sSema4D ,CaN ,MMP14 ,PINP and ICTP con-tents .Conclusion :The changes of three-dimensional speckle tracking parameters GLS and AGS in patients with coronary heart disease are closely related to the changes in signal pathway function ,cytokine secretion and collagen metabolism during left ventricular remodeling .%目的:研究冠心病患者三维斑点追踪参数与左心室重构过程中血清指标变化的相关性.方法:选择我院在2015年3月～2017年5月期间诊断的冠心病心绞痛患者作为研究的C HD组,另取同期在我院体检的健康者作为对照组;比较两组受试者的三维斑点追踪参数、外周血信号分子表达量、血清中细胞因子及胶原代谢指标含量.结果:CHD组患者的GLS 、AGS水平均较对照组志愿者显著降低( P＜0 .05) ,GCS 、GRS水平与对照组志愿者比较无显著变化,外周血中Notch1 、Hes1 、NF-κB 、PKC的表达强度以及血清中sTWEAK 、FGF23 、TGF-β1 、GDF15 、sSema4D 、CaN 、MMP14 、PINP 、ICTP的含量和对照组比均显著升高(P＜0 .05) ;CHD组患者GLS 、AGS的水平与外周血中Notch1 、Hes1 、NF-κB 、PKC的表达强度以及血清中sTWEAK 、FGF23 、TGF-β1 、GDF15 、sSema4D 、CaN 、MMP14 、PINP 、IC-T P的含量呈负相关关系.结论:冠心病患者三维斑点追踪参数GLS 、AGS的变化与左心室重构过程中信号通路功能、细胞因子分泌及胶原代谢的改变密切相关.